Abstract: An analysis method has been established for the determination of 12 components in compound Danshen tablets by high performance liquid chromatography-diode array detector, and it was determined whether there were illegally mixed Panax notoginseng leaves in compound Danshen tablets. The mobile phase was acetonitrile-0.1% aqueous phosphate solution (gradient elution). The sodium Danshensu, protocatechuic acid, protocatechualdehyde, rosmarinic acid, salvianolic acid B, notoginsenoside R₁, ginsenoside Rg₁, ginsenoside Re, ginsenoside Rb₁, ginsenoside Rb₃, tanshinone I, tanshinone II_A were analyzed by changing the wavelengthes and UV spectral scanning qualitative method. The linear relationship of the 12 components was good (r≥0.999 2), and the precision (RSD<2.0%), stability (RSD<2.0%) and recovery rate (96.1%~99.8%) all met the methodological requirements, which can be used for the quality control of compound Danshen tablets.