Abstract: With the development of proteomics and biomass spectrometry, large scale quantitative proteomics has become an important aspectof proteomics. Quantitative proteomics plays important roles in deciphering the biological progress, understanding the development of the disease, and discovering as well as verifying biomarkers for the diagnosis and therapy of diseases.In this review, the status of quantitative proteomics has beenaddressed. The principles, advantages and disadvantages, as well as theapplications of various quantitative proteomics strategieswere summarized and discussed.