Abstract: The safety of plastic food packaging materials is an important part for ensuring food safety. The hazard of bisphenol A migration from the food packing materials to food has attracted the attention of the society. In this paper, plastic food packing materials containing known content of bisphenol A were soaked into three different food stimulants respectively, water, 3% acetic acid (volume fraction) and 10% ethanol (volume fraction). The relationship between the migration contents and the food stimulants was investigated by determining bisphenol A of the immersed liquid. It was found that the migration contents of bisphenol A in different stimulants were different. And the migration order was: 10% ethanol >3% acetic acid > water. In addition, the influential factors on the bisphenol A migration, such as soaking temperature, time and microwave, were systematically studied. The result showed that the migration content of bisphenol A increased as the soaking time prolonged and the temperature raised. Moreover, microwave significantly enhanced the migration content of bisphenol A from the plastic packing materials into food.