Abstract: Due to the remarkable advantages of molecular devices, such as small-size, facile synthesis and easy structural modifications, large storage, fast response, artificial intelligence, etc., the study of molecular devices has become one of the most important research areas arising from multi-discipline subjects (Chemistry, Physics, and Materials, Science) in the 21st century. In the present paper, the recent development in molecular logic devices is reviewed. Various kinds of molecular logic gates, half-adder/subtractor, molecular logic circuit, and DNA computing and molecular computation in solid state systems are introduced. The existing problems of molecular devices and their application prospects are also put forward.