Abstract: A new experimental system of PVT measurement automatically controlled by a computer has been developed. The overall pressure and temperature uncertainty is about ±1.2 KPa, and ±5 mK, respectively. The vapor pressures of HFC-245fa were measured in the temperature range from 294 to 351 K with the new experimental system, and the experimental results indicated that the average deviation between experimental data and the equation provided in the literature was below 0.03%, and the standard deviation was below 0.484%. Which approved that the new experimental system is reliable.