前列泰片在家兔体内的药代动力学研究

Study on the Pharmacokinetics of Qianlietai Tablets after Oral Adminstration in Rabbits

摘要: 应用柱前衍生化HPLC法测定了以%前列泰片悬浮液灌饲(31 mL/kg)家兔后,兔血浆中水苏碱(Stachy-drine)浓度.结果表明水苏碱在家兔血中的经时变化符合二室模型:峰浓度(C_max)6.29±0.8μg/mL;达峰时间(T_max)3.36±0.6h;分布相半衰期(T_1/2α)5.35±3.79 h;消除相半衰期(T_1/2β)32.38±2.33 h;药时曲线下面积(AUC)208.15±118.μg/(mL·h).

Abstract: An analytical method for the determination of stachydrine concentration in rabbits after oral administration with 4% suspension of tablet powder was established. The pharmacokinetics in rabbits is a two compartment model. The main pharmacokinetic parameters are: C_max is 6.29±0.84 μg/mL, T_max is 3.36±0.64 h; T_1/2α is 5.35±3.79 h; T_1/2β is 32.38±24.33 h; AUC is 208.15±118.4 μg/(mL·h).