α-乙酰氨基-β-4-(1, 2-二氢-2-硫代喹啉)丙酸乙酯的合成及结构鉴定

Synthesis and Structural Identification of α-Acetylamino-β-4-(1, 2-dihydro-2-thioquinoline) Propionic Acid Ethyl Ester

摘要: α-乙酰氨基-β-4(1,2-二氢-2-氧代喹啉)丙酸乙酯以五硫化二磷为硫化剂,经选择性硫代反应合成新化合物α-乙酰氨基-β-4(1,2-二氢-2-硫代喹啉)丙酸乙酯,并使用IR、UV、NMR、GC/MS及元素分析对其结构进行了鉴定.

Abstract: The selective thionation of α-acetylamino-β-4(1,2-dihydro-2-oxoquinoline)propionic acid and its ester with phosphorus pentasulfide as a thionation reagent yielded the target compound α-acetylamino β-4(1,2-dihydro-2-thioquinoline)propionate. The structure of the new compound was studied by IR、UV、¹³C NMR、GC/MS and Element analysis,and substitutional site of thionation of acetylamine was discussed.