Abstract: The high performance liquid chromatography (HPLC) /triple quadrupole mass spectrometry method for analysis and sample pretreatment of 15 sunscreens commonly in sunscreen cosmetics was established. 1 mL of anhydrous ethanol was added to the sample, and the volume of the sample was fixed with acetonitrile∶water (volume ratio: 4∶1). After ultrasonic extraction, the sample was purified by a QuEChERS column, centrifuged at 0 ℃ for 10 min at 10 000 r/min. The sample was used as mobile phase with acetonitrile solution cotaining 0.1% formic acid-2 mmol/L ammonium acetate solution containing 0.1% formic acid, and then gradient elution was performed. The separation was carried out on a C18 (2.1 mm × 50 mm, 1.8 µm) column, scanned in positive ion mode with multiple reaction monitoring (MRM) and quantified by external standard method. The results showed that the 15 sunscreens showed good linearity in a certain concentration range, and the correlation coefficient was greater than 0.99. The detection limits of the method were 10~50 μg/kg. The average recoveries were 68.4%~84.2%, and the relative standard deviations (RSD) were 1.7%~9.0%. The method has a high sensitivity, good reproducibility and good adaptability for the detection of sunscreens.