Abstract: By using the network survey method, the establishment of domestic instrument development projects in Zhejiang Province, the situation of A-share listed companies in the national instrumentation industry and the application status of domestic scientific research instrument in Zhejiang Province were obtained from the Zhejiang Science and Technology Brain, Juchao Information Network, and the large-scale scientific research instrument opening and sharing platform in Zhejiang Province. And the obtained data were analyzed, and then the development status of domestic scientific research instrument in Zhejiang Province was sorted out, the existing problems were pointed out, and corresponding countermeasures and suggestions were put forward.