Abstract: In order to determine the Ginsenoside Rg₁, Ginsenoside Re and Ginsenoside Rd in Shengqi Jiangtang Capsule rapidly, a high performance liquid chromatographic (HPLC) method has been set up. Under optimized conditions, the analytes were carried out with acetonitrile, water as the mobile phase in a gradient elution manner at a flow rate of 0.43 mL/min and a wavelength of 203 nm on a 3.5 μm Coreshell column(3.0 mm×150 mm). The results showed that good linear relationships of Ginsenoside Rg₁, Ginsenoside Re and Ginsenoside Rd within the mass concentrations of 5~400, 20~800, 5~400 μg/mL, respectively, and all the correlation coefficients were better than 0.999 6. The recoveries were 95.89%~100.67% and the relative standard deviations were 1.04%~3.39%. This rapid, accurate and reliable method can be used for the quality control of Shengqi Jiangtang Capsule without a high demand instrument.