Abstract: Micro-confocal Raman spectrometer can be effectively used to analyze the chemical composition, microstructure, stress-strain and other characteristics of substances. As a high-frequency analysis device, it is widely used in life, medicine, food, chemistry, materials and other fields, and plays an important role in the Raman research. The working principle and usage of InVia-Reflex micro-confocal Raman spectrometer were introduced, and the typical problems of laser damage to samples, change of Raman spectral characteristics caused by the change of laser intensity, the hiding of Raman signal in the strong background signal were analyzed. The corresponding solutions were given. Finally, how to effectively manage and maintain the equipment were described in detail, so as to improve the use efficiency of the instrument and provide management experience for the operation of the same type of instrument.