Abstract: At present, the instrument management of life research institutions is mainly based on experience management. In the process of actual management, some problems may arise, so it is necessary to analyze and solve the current problems from the perspective of management. First, use the reference of the concept of the internet platform to analyze the organization construction of the instrument platform. Then carry out the economic analysis of the relationship between the instrument platform and the research team. The staff of the instrument platform should understand the characteristics of management activities under the thinking framework of life science. Suggestion on the research of organizational structure to give the instrument platform an independent and parallel with the scientific research team position and the cost of the instrument is subject to a floating mechanism. It is proposed that the training and selection of the staff in the instrument platform and managers must be based on to improve the ability of the management, and relevant measures should put forward.