Abstract: The pretreatment methods described by quick, easy, cheap, effective, rugged, and safe (QuEChERS) and NY/T 761-2008 were used to treat several tested agricultural samples, then the residue of organochlorine pesticide content of the tested samples was determined by gas chromatography, and the detection results were compared. The results showed that, the average spiked recoveries of the 18 residues of organochlorine pesticides of tested vegetable samples ranged from 72.1%~123.9%, with the relative standard deviations of 0.5%~19.1%. 72.2% of the pesticides detection limits (LODs) were above or equal to NY/T 761-2008 method, only 27.8% were below the NY/T 761-2008 method. The analysis results of several vegetable materials confirmed that the pretreatment by QuEChERS can meet the requirement of determination methods for multi-pesticide residue analysis by GC, and accurate and reliable results were obtained. Due to the low consumption of organic solvent, fast processing rate, strong selectivity, high recovery, high precision and strong practicality, when the pretreatment of QuEChERS could replace of NY/T 761-2008 in the detection of organochlorine pesticide residues in general cases.